Mutations are the fastest way to scale your passive income in Anime Card Collection. They transform ordinary cards into high-yield assets by applying material variants that multiply earnings. Understanding how mutations work and how to trigger them is essential for accelerating progression.
Quick answer: Mutations multiply card cash earnings by 3x (Gold), 5x (Emerald), 10x (Void), 25x (Diamond), or 70x (Rainbow). Higher tiers are rarer but dramatically increase income per card.
What mutations do
A mutation is a material variant applied to a card pack that increases the cash output of every card inside it. If a base card earns $20 per second, a Gold-mutated version of that same card earns $60 per second. The multiplier stacks with card level, grade, and other income modifiers, making mutations one of the most direct ways to boost earnings.
Mutations appear on packs as they spawn on the conveyor belt or refresh in the Card Market. When you open a mutated pack, all cards inside carry that mutation's multiplier permanently. This means a single high-tier mutated card can generate more income than dozens of unmodified ones.

The five mutation tiers
| Tier | Multiplier | Rarity |
|---|---|---|
| Gold | 3x | Common |
| Emerald | 5x | Uncommon |
| Void | 10x | Rare |
| Diamond | 25x | Very rare |
| Rainbow | 70x | Extremely rare |
Gold mutations are the most frequent and offer a solid 3x boost. Emerald and Void mutations appear less often but deliver stronger returns. Diamond and Rainbow mutations are uncommon enough that many players will focus on accumulating mid-tier mutations first before chasing the rarest variants.
Increasing mutation spawn rates
Mutation Chance is a stat that controls how often packs spawn with a mutation. The higher your Mutation Chance, the more frequently you'll see Gold, Emerald, Void, Diamond, and Rainbow packs appear.
The most effective way to boost Mutation Chance is upgrading the Upgrade Machine. At maximum level 40, it grants +266.67% Mutation Chance, plus additional bonuses like 44.47% faster hatch time, +10 walk speed, and +4% global luck. This single upgrade path delivers the largest mutation rate increase available.
Crafting Relics also increases Mutation Chance. Unlocking all 14 Relics in the game adds +19.5% Mutation Chance cumulatively. Each Relic requires completing a full card collection and spending material packs, so this is a long-term investment. Achievements provide smaller permanent boosts as well.

Duplicate cards and experience
When you pull a duplicate card with a mutation, the duplicate contributes to leveling the base card while the mutation bonus applies to experience gains. Higher mutation tiers grant more experience per duplicate, accelerating card level growth. This means mutated duplicates serve double duty: they level your cards faster, and the leveled cards earn more per second.
Mutations transform card collection from a slow grind into exponential growth. Prioritizing Mutation Chance upgrades early and actively hunting for higher-tier mutations will dramatically compress your timeline to building a high-income album.