The Sanctum of Transcendence is an Abyss puzzle in Crimson Desert that requires you to destroy three pixelated barriers, manipulate a movable block, and activate a circular mechanism. Completing the challenge rewards you with an Abyss Artifact. The sanctum is located in the Dry Valley region and can be accessed once you've unlocked the necessary progression to interact with Abyss Nexus sites.
Quick answer: Shatter all three pixelated walls using Force Palm: Focus, pull the block beneath the third opening with Axiom Force, drop down onto it, then activate the circular mechanism and interact with the central platform to obtain the artifact.

Sanctum of Transcendence Location
The Sanctum of Transcendence is marked on the map in the Dry Valley region. When you hover over the location marker, the description reads: "The Abyss of mortal earth that tore through the sky. Only the brave to devote yourself to one place shall guide the path before you." You'll need to travel to this marker and approach the ruined structure to begin the puzzle.
The entrance involves a grappling section where you launch yourself across a gap toward the large stone ruins. Once inside, you'll encounter the first pixelated wall immediately.
Breaking the Pixelated Walls
Step 1: Approach the first pixelated wall. An interaction prompt will appear with options including "Unlock," "Cancel," "Force Palm: Focus," and "Nature's Snare." Select Force Palm: Focus to shatter the wall.

Step 2: Walk through the opening into a small room containing a glowing white orb. Continue forward to the second pixelated wall and use Force Palm: Focus again to destroy it.
Step 3: After breaking the second wall, look down through the opening. You'll see a movable block on the floor below. Do not drop down yet—you need to reposition this block first.

Repositioning the Block
Step 1: Use Axiom Force to grab the block from above. On-screen prompts will show "Pull/Push," "Move," "Rotate," and "Cancel." Pull the block directly beneath the opening you're standing in.

Step 2: Once the block is centered under the opening, drop down onto it. The block serves as a platform to reach the third pixelated wall.
Step 3: Face the third pixelated wall and shatter it with Force Palm: Focus. Behind this wall is a large circular mechanism.

Activating the Mechanism and Completing the Puzzle
Step 1: Jump toward the circular mechanism. An interaction prompt will appear with options including "Raise Lantern," "Axiom Force," "Deactivate," "Accelerate," and "Aerial Roll." Activate the mechanism.

Step 2: Drop down from the mechanism and follow the glowing line on the floor. This line leads to the central platform of the sanctum.
Step 3: Interact with the central platform. A beam of light will shoot upward, and an on-screen notification will confirm: "Quest Completed: Sanctum of Transcendence." The objective "Obtain the artifact" will be marked complete.

You can verify completion by opening your Journal and navigating to the Challenges tab. The Sanctum of Transcendence entry will show all objectives checked, including "Activate the Abyss Nexus," "Restore the Abyss," and "Obtain the artifact." The reward listed is Abyss Artifact x1.
Prerequisites and Unlocking Sanctums
Sanctums in Crimson Desert are tied to specific quest chains involving the Witches. You must unlock Elowen, the Witch of Wisdom, during Chapter 5 of the main story before you can complete any sanctum puzzles. Even if you solve the puzzle steps correctly, the sanctum will not register as complete until you've met this prerequisite.
Elowen can be found near the Witchwoods, southwest of Hernand City. After unlocking her as a merchant in Chapter 5, she will provide quests that allow you to cleanse all sanctums, including the Sanctum of Transcendence. If you attempt to cleanse a sanctum before meeting Elowen, you may receive a message indicating you need to find a specific person first.

The Sanctum of Transcendence puzzle is straightforward once you understand the sequence: destroy the barriers, reposition the block to access the mechanism, and activate the central platform. Make sure you've progressed far enough in the main story to unlock Elowen before attempting any sanctum, or your progress won't register.